Noncoding Genomic Informatics
microRNAs (miRNA) are a class of small non-coding regulatory RNAs, which may to mRNAs to cause degradation or translation inhabitation for the targeting mRNAs.
Genetic variations in microRNA seed region or binding site can disrupt the interaction between the microRNA and the mRNA, rewire the microRNA regulatory networks, and cause various diseases.
PolymiRTS (Polymorphism in microRNAs and their Target Sites) is a database of DNA variations in microRNA seed regions and microRNA target sites.
MicroRNAs can bind to many types of RNAs, including mRNA, circular RNAs (circRNAs), and long noncoding RNAs (lncRNAs).
These RNAs are called competing en-dogenous RNAs (ceRNAs) as they compete for the binding of microRNAs.
The ceRNAs can regulate the abundance of a microRNA-targeting mRNA by competing for the microRNA binding.
The aberrant microRNA-ceRNA interactions are associated with many types of cancers.
SomamiR is a database of cancer somatic mutations in microRNAs and their target sites that potentially alter the interactions between miRNAs and ceRNAs, including mRNAs, circRNAs and lncRNAs.
The CTCF protein functions as a genomic insulator, which sets boundaries to block the interaction between enhancers and promoters. It is also important for 3D organization of the genome.
The CFCF-binding site database is a collection of known CTCF binding sites.
It also provides tools for the prediction and functional analysis of the CTCF binding sites.